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42406 cgas mouse  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc 42406 cgas mouse
    FIGURE 4. NR mitigated damaged DNA-stimulated <t>cGAS-STING</t> pathway. (A) Representative microscopic images of dsDNA immunopositivity (in red) and DAPI-counterstained nuclei (in blue). Scale bar: 50 μm. The boxed areas within the images were magnified and displayed in the right panels (arrowheads). Scale bar: 10 μm. (B) Colocalization of Tom20 (green), dsDNA (red), and DAPI (blue) expressions in retinas of each group (arrows). Scale bar: 10 μm. (C) Heatmap of cGAS and STING from RNA sequencing of naive and LIRD retinas with or without NR treatment (n = 4/group). (D) Colocalization of cGAS (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (E) Quantification of cGAS-positive microglia of each group in the ONL at three days after light exposure (n = 4–6/group). (F) Colocalization of STING (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (G) Quantification of STING-positive microglia of each group in the ONL at three days after light exposure (n = 5–6/group). NR treatment significantly decreased the expression of cGAS and STING compared with the PBS-treated group, ****P < 0.0001.
    42406 Cgas Mouse, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 759 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/42406 cgas mouse/product/Cell Signaling Technology Inc
    Average 99 stars, based on 759 article reviews
    42406 cgas mouse - by Bioz Stars, 2026-03
    99/100 stars

    Images

    1) Product Images from "Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis."

    Article Title: Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis.

    Journal: Investigative ophthalmology & visual science

    doi: 10.1167/iovs.66.4.14

    FIGURE 4. NR mitigated damaged DNA-stimulated cGAS-STING pathway. (A) Representative microscopic images of dsDNA immunopositivity (in red) and DAPI-counterstained nuclei (in blue). Scale bar: 50 μm. The boxed areas within the images were magnified and displayed in the right panels (arrowheads). Scale bar: 10 μm. (B) Colocalization of Tom20 (green), dsDNA (red), and DAPI (blue) expressions in retinas of each group (arrows). Scale bar: 10 μm. (C) Heatmap of cGAS and STING from RNA sequencing of naive and LIRD retinas with or without NR treatment (n = 4/group). (D) Colocalization of cGAS (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (E) Quantification of cGAS-positive microglia of each group in the ONL at three days after light exposure (n = 4–6/group). (F) Colocalization of STING (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (G) Quantification of STING-positive microglia of each group in the ONL at three days after light exposure (n = 5–6/group). NR treatment significantly decreased the expression of cGAS and STING compared with the PBS-treated group, ****P < 0.0001.
    Figure Legend Snippet: FIGURE 4. NR mitigated damaged DNA-stimulated cGAS-STING pathway. (A) Representative microscopic images of dsDNA immunopositivity (in red) and DAPI-counterstained nuclei (in blue). Scale bar: 50 μm. The boxed areas within the images were magnified and displayed in the right panels (arrowheads). Scale bar: 10 μm. (B) Colocalization of Tom20 (green), dsDNA (red), and DAPI (blue) expressions in retinas of each group (arrows). Scale bar: 10 μm. (C) Heatmap of cGAS and STING from RNA sequencing of naive and LIRD retinas with or without NR treatment (n = 4/group). (D) Colocalization of cGAS (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (E) Quantification of cGAS-positive microglia of each group in the ONL at three days after light exposure (n = 4–6/group). (F) Colocalization of STING (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (G) Quantification of STING-positive microglia of each group in the ONL at three days after light exposure (n = 5–6/group). NR treatment significantly decreased the expression of cGAS and STING compared with the PBS-treated group, ****P < 0.0001.

    Techniques Used: RNA Sequencing, Expressing



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    42406 cgas mouse  (Cell Signaling Technology Inc)
    99
    Cell Signaling Technology Inc 42406 cgas mouse
    FIGURE 4. NR mitigated damaged DNA-stimulated <t>cGAS-STING</t> pathway. (A) Representative microscopic images of dsDNA immunopositivity (in red) and DAPI-counterstained nuclei (in blue). Scale bar: 50 μm. The boxed areas within the images were magnified and displayed in the right panels (arrowheads). Scale bar: 10 μm. (B) Colocalization of Tom20 (green), dsDNA (red), and DAPI (blue) expressions in retinas of each group (arrows). Scale bar: 10 μm. (C) Heatmap of cGAS and STING from RNA sequencing of naive and LIRD retinas with or without NR treatment (n = 4/group). (D) Colocalization of cGAS (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (E) Quantification of cGAS-positive microglia of each group in the ONL at three days after light exposure (n = 4–6/group). (F) Colocalization of STING (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (G) Quantification of STING-positive microglia of each group in the ONL at three days after light exposure (n = 5–6/group). NR treatment significantly decreased the expression of cGAS and STING compared with the PBS-treated group, ****P < 0.0001.
    42406 Cgas Mouse, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/42406 cgas mouse/product/Cell Signaling Technology Inc
    Average 99 stars, based on 1 article reviews
    42406 cgas mouse - by Bioz Stars, 2026-03
    99/100 stars
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    Image Search Results


    FIGURE 4. NR mitigated damaged DNA-stimulated cGAS-STING pathway. (A) Representative microscopic images of dsDNA immunopositivity (in red) and DAPI-counterstained nuclei (in blue). Scale bar: 50 μm. The boxed areas within the images were magnified and displayed in the right panels (arrowheads). Scale bar: 10 μm. (B) Colocalization of Tom20 (green), dsDNA (red), and DAPI (blue) expressions in retinas of each group (arrows). Scale bar: 10 μm. (C) Heatmap of cGAS and STING from RNA sequencing of naive and LIRD retinas with or without NR treatment (n = 4/group). (D) Colocalization of cGAS (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (E) Quantification of cGAS-positive microglia of each group in the ONL at three days after light exposure (n = 4–6/group). (F) Colocalization of STING (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (G) Quantification of STING-positive microglia of each group in the ONL at three days after light exposure (n = 5–6/group). NR treatment significantly decreased the expression of cGAS and STING compared with the PBS-treated group, ****P < 0.0001.

    Journal: Investigative ophthalmology & visual science

    Article Title: Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis.

    doi: 10.1167/iovs.66.4.14

    Figure Lengend Snippet: FIGURE 4. NR mitigated damaged DNA-stimulated cGAS-STING pathway. (A) Representative microscopic images of dsDNA immunopositivity (in red) and DAPI-counterstained nuclei (in blue). Scale bar: 50 μm. The boxed areas within the images were magnified and displayed in the right panels (arrowheads). Scale bar: 10 μm. (B) Colocalization of Tom20 (green), dsDNA (red), and DAPI (blue) expressions in retinas of each group (arrows). Scale bar: 10 μm. (C) Heatmap of cGAS and STING from RNA sequencing of naive and LIRD retinas with or without NR treatment (n = 4/group). (D) Colocalization of cGAS (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (E) Quantification of cGAS-positive microglia of each group in the ONL at three days after light exposure (n = 4–6/group). (F) Colocalization of STING (red) and Iba1-positive microglia (green) expression in the retinas of each group (arrows). Scale bar: 30 μm. (G) Quantification of STING-positive microglia of each group in the ONL at three days after light exposure (n = 5–6/group). NR treatment significantly decreased the expression of cGAS and STING compared with the PBS-treated group, ****P < 0.0001.

    Article Snippet: Iba-1 Rabbit 1:500 Abcam* ab178846 Iba-1 Goat 1:800 Abcam* ab5076 CD68 (FA-11) Rat 1:200 Thermo† 14-0681-82 dsDNA Mouse 1:200 Santa Cruz‡ sc-58749 Tom20 (D8T4N) Rabbit 1:200 Cell Signaling Technology§ 42406 Cgas Mouse 1:200 Santa Cruz‡ sc-515777 STing Rabbit 1:200 Proteintech║ 19851-1-AP NLRP3 Rabbit 1:200 Abmart¶ P60622R3 Casepase-1 Mouse 1:100 Santa Cruz‡ sc-56036 IL-1β Mouse 1:100 Cell Signaling Technology§ 12242 GSDMD Mouse 1:200 Santa Cruz† sc-393581 Goat Anti-Rabbit IgG H&L (Alexa Fluor 488) Goat 1:400 Jackson# 111-545-003 Goat Anti-Rat IgG H&L (Alexa Fluor 594) Goat 1:300 Jackson# 112-505-175 Donkey Anti-Rabbit IgG H&L (Alexa Fluor 488) Donkey 1:400 Thermo† A21206 Donkey Anti-Mouse IgG H&L (Alexa Fluor 555) Donkey 1:400 Thermo† A31570 Donkey Anti-goat IgG H&L (Alexa Fluor 568) Donkey 1:400 Thermo† A11057 * Abcam, Cambridge, MA, USA.

    Techniques: RNA Sequencing, Expressing